Dr. Neo Cortex is a professional scientist born in Peoria, Illinois, and is the primary antagonist of the Crash Bandicoot series. He is Crash Bandicoot's arch-nemesis and creator, and has been seen throughout the series with colleagues such as Dr. Nitrus Brio, Dr. N-Gin, and Uka Uka; animal henchmen such as Tiny Tiger and Dingodile, and his niece Nina Cortex.
In Skylanders: Imaginators, Neo Cortex is one of the Tech Senseis and now trains Imaginators who belong to the Sorcerer Battle Class. He is available with Crash (who is a Brawler Sensei of the Life element) in the Crash Edition Starter Pack for PlayStation 3 and PlayStation 4 (though they're both playable on other consoles), alongside the original components of the regular starter pack: King Pen, Golden Queen, and a Fire Creation Crystal. He and Crash are also available in the Thumpin' Wumpa Islands Adventure Pack for those who want to buy them separately.
A wormhole has opened in Skylands and the great Aku Aku appears! He comes to announce the once-in-two-decades Synchronization Celebration -- it is the time when all the worlds align perfectly. All the inhabitants of Wumpa Island are having a huge party in the Wumpa Islands and want to invite the Skylanders. But Dr. Neo Cortex has created a sinister machine to harness this incredible energy for his own evil purposes, only to watch it go completely haywire. Now Dr. Neo Cortex must partner with Crash Bandicoot to stop the machine before Wumpa Islands are completely shaken apart!
In the Thumpin' Wumpa Islands Adventure Pack, Dr. Neo Cortex had planned an evil scheme for 20 years to create an army of unstoppable minions using the rhythmic energies of the Synchronization Celebration that took place on the Island. However his Cortex Matrix Chamber was hijacked by his minion Fake Crash, causing an explosion that sent Cortex rocketing towards the island beach. He is then forced to partner with his nemesis, Crash Bandicoot, and the Skylanders to stop Fake Crash from destroying Wumpa Island with bad rhythms. After Fake Crash's defeat, Cortex was dismayed that his Cortex Matrix Chamber was turned into a docile music box by Mags and was last seen glaring angrily at Crash.
As his original creator, Cortex holds a deep hatred for Crash Bandicoot. Whenever Cortex tries to take over the world, Crash always steps in and saves the day, which deeply irritates Cortex.
However, now that they're Skylanders, the scientist and the marsupial are now on much friendlier terms with one another, even though they are often annoyed at each other's personal antics.
Uka Uka is Cortex's boss and the brother to Aku Aku. Uka Uka is always angry at Cortex and his constant failure to take over the world.
- "At last! 20 years of meticulous planning, preparations and machinations have all built to this single moment! The fathomless rhythmic energies of Wumpa Island itself shall power my Cortex Matrix Chamber and create an unstoppable army of loyal minions! And this time, none of my stupid henchmen will be around to ruin it for me! MWAHAHAHAHA!"
- "What did you do to my beautiful machine?!"
- "Let's get those Imaginators ready for total world domi- I mean, awesomely heroic do-gooding! And stuff." - Sensei Training Bonus
- "And when you want to put your mind to learning some Secret Sorcerer Techniques, you just say so!" - Secret Technique Bonus
- "If you're looking to make your Imaginators more powerful, you have come to the right place!" - Unused Sensei Training Bonus quote
- "And I of course possess a highly classified, supremely secret, scientifically approached, technique just for Sorcerers!" - Unused Secret Technique Bonus quote
- "How do you like them apples?"
- "Another win for Cortex!
- "Do you want to see power?!" - Sky-Chi (Rehabilita-Laser)
- The tables have turned!" - Sky-Chi (Rehabilita-Laser)
- "You never had a chance!" - End of Sky-Chi
- "Patience is not my virtue."
- "The doctor is in!"
- "Can't stop progress!"
- "I'm back, baby!"
- "You can hear me growing smarter!" - when checking stats
- "Ooh, Who knew you could improve on perfection."
- Cortex and Boom Bloom are the only Senseis to not have a weapon from their battle classes. While Cortex can turn his weapon into a staff, he mainly wields a gun.
- Unlike Boom Bloom however, Cortex's unlockable weapon is not for the battle class he is in, but is instead for the quickshot battle class.
- Cortex is the first Skylander to be human, though because of his original series' art style, he does not appear to be one.
- His name is a pun on neocortex, the largest part of the brain.
- Just as with Crash, characters in Thumpin' Wumpa Islands will have custom dialogue if you play as Cortex. In his case, they will act untrustworthy towards him (rightfully), believing he is the cause of the problem in some way.
- He and Crash are two of the characters to also act as Adventure Pack figures, adding Thumpin' Wumpa Islands to the game. The others include Wild Storm, adding Cursed Tiki Temple, and Ro-Bow, adding Lost Imaginite Mines.
- Despite being the only Guest Star who is able to talk freely, like the other Guest Stars, he does not have a catchphrase.
- Cortex is the second villain who did not appear in Trap Team to have a Skylander figurine (The first is Hammer Slam Bowser).
- Unlike Hammer Slam Bowser and Turbo Charge Donkey Kong who are only exclusive to Nintendo, he and Crash Bandicoot are the first and only guest characters that can be played in any gaming consoles.
- On his figure he bares white sleeves. However, ingame he has black sleeves.
- In his artwork and on his figure, his gun is completely silver-colored. However, ingame only the muzzle of the gun is silver while the body is red and yellow.
- During a Grind Challenge, he slides only on his left foot.